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Synapedia is an independent knowledge project about psychoactive substances and harm reduction. If the platform helps you learn something new, you can support its development.
Every bit helps keep the project alive.
Note: This tool is for scientific education only. Results do not replace medical advice and do not constitute an encouragement to use substances.
Select two substances to check potential interactions.
The Synapedia Interaction Checker identifies known pharmacological interactions between psychoactive substances using curated, source-backed data. Each interaction entry includes the underlying mechanism conflict, a risk rating, and concrete harm-reduction guidance.
Explore substance relationships visually in the Knowledge Graph or compare two substances side by side in the Comparison Tool.
The Interaction Checker is based on curated data from pharmacological literature and PubMed publications. It is intended for scientific education only and does not replace medical advice. Not all interactions are covered — always consult healthcare professionals when in doubt.