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N-methyl-3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propan-1-amine
Nortriptyline is a tricyclic antidepressant that primarily acts by inhibiting the reuptake of norepinephrine and serotonin. It also possesses anticholinergic and antihistaminergic properties, which can lead to sedating effects. The substance is mainly used for the treatment of depression and can cause side effects such as dry mouth and drowsiness. Due to its pharmacological profile, careful medical monitoring is required.
Receptor Targets
Mechanism of Action
Nortriptyline acts through the following pharmacological mechanisms:
Designations
IUPAC: methyl-[3-(2-tricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaenylidene)propyl]amine
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der 5-HT2A-Rezeptor ist ein Serotonin-Rezeptor der Klasse Gq-gekoppelter GPCRs. Er ist der primäre molekulare Angriffspunkt klassischer Psychedelika und spielt eine Rolle bei Kognition und Wahrnehmung.
Der Serotonintransporter (SERT/5-HTT) ist ein Natrium-abhängiger Monoamintransporter, der Serotonin aus dem synaptischen Spalt zurück in die präsynaptische Zelle transportiert. Er ist das primäre Ziel von SSRI und MDMA.
Der Noradrenalintransporter (NET) ist ein Monoamintransporter, der Noradrenalin aus dem synaptischen Spalt zurücktransportiert. Er wird von verschiedenen Stimulanzien und Antidepressiva beeinflusst.
Der H1-Rezeptor ist ein Gq/11-gekoppelter Histaminrezeptor, der an allergischen Reaktionen, Wachheit und Thermoregulation beteiligt ist. Antagonismus verursacht Sedierung und wird therapeutisch als Schlafhilfe und Antiallergikum genutzt.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some content may appear in German.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 24 hours
Peak
4-6 weeks
Onset
1-3 weeks
Total duration
24 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Sedierung, Mundtrockenheit und Gewichtszunahme.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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