Timeline Explorer

What is a substance timeline?

A substance timeline describes the temporal sequence and intensity of pharmacological effects — from initial onset through the peak experience to the comedown and afterglow. These phases vary depending on the substance, route of administration, dose, and individual factors such as body weight and tolerance.

Effect phases overview

Onset

First noticeable effects after administration. Duration depends heavily on the route — sublingual and insufflated routes often act faster than oral.

Come-up

Effects progressively intensify. Physical symptoms such as stomach discomfort may occur.

Peak

Height of the experience. Strongest psychoactive and physiological effects.

Plateau

Stabilized phase after the peak. Intensity remains at a constant level.

Comedown

Effects gradually diminish. Residual effects and fatigue may begin.

Afterglow

Lingering effects after the main experience ends. Can last hours to days.

Methodology and data sources

All time ranges are based on an aggregation of clinical studies, peer-reviewed publications, and validated community data. Effect phases are given as ranges (e.g., 20–60 minutes) since individual experiences vary considerably. Data quality is transparently indicated for each substance.