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cis-(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenylcyclopropane-1-carboxamide
Milnacipran is a selective serotonin-norepinephrine reuptake inhibitor primarily used for the treatment of depression and fibromyalgia. It works by inhibiting the reuptake of serotonin and norepinephrine in the central nervous system, which increases the availability of neurotransmitters. The substance has a moderate adverse effects profile and is often used in patients who do not respond adequately to other antidepressants.
Receptor Targets
Mechanism of Action
Designations
IUPAC: cis-(1R,2S)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der Serotonintransporter (SERT/5-HTT) ist ein Natrium-abhängiger Monoamintransporter, der Serotonin aus dem synaptischen Spalt zurück in die präsynaptische Zelle transportiert. Er ist das primäre Ziel von SSRI und MDMA.
Der Noradrenalintransporter (NET) ist ein Monoamintransporter, der Noradrenalin aus dem synaptischen Spalt zurücktransportiert. Er wird von verschiedenen Stimulanzien und Antidepressiva beeinflusst.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some content may appear in German.
Milnacipran wirkt durch die Hemmung der Wiederaufnahme von Serotonin und Noradrenalin im zentralen Nervensystem, was zu einer erhöhten Verfügbarkeit dieser Neurotransmitter führt.
Total duration Long-term use
Peak
4-6 weeks
Onset
1-2 weeks
Total duration
Long-term use
After effects
Variable
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Übelkeit, Schwindel und Schlaflosigkeit.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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