Synapedia

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Phenelzine

Phenelzine is an irreversible monoamine oxidase inhibitor used for the treatment of depression. It increases the availability of neurotransmitters such as serotonin, norepinephrine, and dopamine by inhibiting the MAO-A and MAO-B enzymes. Due to its mechanism of action, there is an increased risk of interactions with certain foods and medications, which can lead to severe side effects.

Antidepressiva
Antidepressiva
Monoaminoxidase A
Monoaminoxidase B

Mechanism of Action

Names / Identifiers

IUPAC: Phenelzine

Phenelzine
51-71-8
2-Phenylethylhydrazine
Phenethylhydrazine
Hydrazine, (2-phenylethyl)-
Fenelzyne
Fenelzyna
beta-Phenylethylhydrazine
(2-phenylethyl)hydrazine
Phenelzinum

Mechanism of Action

Phenelzine wirkt als nicht-selektiver Hemmer der Monoaminoxidase, was zu einer erhöhten Verfügbarkeit von Neurotransmittern wie Serotonin, Noradrenalin und Dopamin im synaptischen Spalt führt.

Effects

Antidepressiv
Angstlösend
Stimmungsaufhellend
Euphorisierend
Appetitanregend
Sedierend

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peaknot specified
NotesEffects may build up over several weeks.
Onset2-4 weeks
Totalnot specified
After Effectsnot specified

Risks & Warnings

Warnings

  • Liver diseases
  • Cardiovascular diseases
  • Concurrent use of other MAO inhibitors

Known Risks

  • medium
  • Mögliche Nebenwirkungen und Wechselwirkungen mit anderen Medikamenten.

Safer Use

  • Regular medical monitoring.
  • Avoidance of tyramine-containing foods.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Triptans
  • Sympathomimetics

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USVerschreibungspflichtig
NotesPhenelzine ist in vielen Ländern als Antidepressivum zugelassen.

Not legal advice. Status may change.