Alkohol / Ethanol & Ketamin

High Risk: Additive central nervous system depression

High RiskSubstance-specific1 Shared Receptors

Risk Assessment

High Risk

Ketamine and alcohol both depress central nervous system activity. Used together they can produce stronger than expected sedation, impaired motor control, disorientation and, at higher levels, reduced consciousness. This raises the risk of falls, accidents, vomiting and airway obstruction while sedated.

Pharmacological Mechanism

NMDA-Antagonismus + GABAerge Potenzierung = additive ZNS-Depression

Mechanism data is language-neutral pharmacological notation.

Substance Profiles

Alkohol / Ethanol

Depressiva

GABA-A-PotenzierungNMDA-AntagonismusEndorphinfreisetzung

GABA-ANMDA

Ketamin

Dissoziativa

NMDA-Antagonist

NMDA

Shared Receptors

Both substances bind to the following receptors, increasing the risk of pharmacological interactions.

NMDA

Evidence Base

Curated Interaction DataAvailable

Data ProvenanceSubstance-specific

Community Mentions0

Shared Receptors1

Sources

Safer Use Guidelines

The combination of ketamine and alcohol can cause deeper sedation than either substance alone and increases the risk of loss of consciousness.
An unconscious or heavily sedated person should be placed in the recovery position; if breathing is impaired or they cannot be woken, call emergency services immediately.
Because both substances impair coordination and judgement, the risk of injury and choking is substantially elevated.

This page is based on curated pharmacological data and/or community signals. It is intended for scientific education and harm reduction only. It does not replace professional medical advice. Not all interactions are covered — always consult a healthcare professional when in doubt. In emergencies, call your local emergency number.

Laden…