Laden…
Gamma-hydroxybutyrate (GHB) is an endogenous CNS depressant that acts primarily at GABA-B receptors and specific GHB receptors. Its narrow therapeutic window and high abuse potential make accurate dosing critical.
Class
Depressiva
Pharmacological context
Mechanism
GABA-B-Agonist, GHB-Rezeptor-Agonist
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
GHB acts through the following pharmacological mechanisms:
Receptor Profile
Der GABA-B-Rezeptor ist ein Gi/Go-gekoppelter metabotroper GABA-Rezeptor, der als Heterodimer (GABA-B1/B2) funktioniert. Er moduliert die Neurotransmitterfreisetzung und vermittelt langsame inhibitorische postsynaptische Potenziale.
Synapedia Evidence
Frequently checked combinations
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Risks & Harm Reduction translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
Depressant-risk context
This substance belongs to a context where combinations with opioids, benzodiazepines, alcohol, GHB/GBL, or other sedating substances can increase sedation, blackout, aspiration, and breathing-risk patterns. Risk Check can review warning patterns; it is not medical advice and it cannot clear a combination as safe.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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The signal hub collects approved risk signals, experience reports and source leads by relevance.
These curated terms are linked deterministically to the structured substance profile. They do not describe frequency or strength and do not replace the monograph's claims.