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Synapedia is a real-time risk intelligence layer for pharmacological interactions. Mechanism-aware analysis, confidence scoring, and actionable mitigation — in a single API call.
360+ substances · 48 curated interaction pairs · mechanism-level pharmacology
Live Example
This isn't a lookup table. It's a mechanism-level analysis that explains why a combination is dangerous — and what to do about it.
Serotonin excess via SERT reversal + reuptake block
Serotonin syndrome — hyperthermia, seizures, death
Never combine. No safe dose. Wait ≥5 half-lives.
Severity: HIGH · Confidence: 92%
3 PubMed sources · mechanism verified
The Problem
Most drug interaction APIs return a single label: "contraindicated." No mechanism. No confidence level. No mitigation. For clinicians and developers building safety-critical tools, that's not enough.
| Dimension | Generic APIs | Synapedia |
|---|---|---|
| Severity scoring | Binary (safe / unsafe) | Granular severity + confidence % |
| Mechanism data | None — just a label | Pathway-level pharmacology |
| Confidence scoring | Not provided | Per-result reliability score |
| Mitigation guidance | "Avoid combination" | Actionable clinical steps |
| Real-world context | Lab data only | Community reports + clinical data |
| Source transparency | Opaque | PubMed IDs per result |
The Solution
Synapedia combines structured pharmacology data, mechanism-level analysis, and confidence scoring into a single API. Think of it as the intelligence layer between your product and pharmacological risk.
Not just "dangerous" — we tell you the pharmacological pathway. SERT reversal, CYP inhibition, receptor competition. The science behind the risk.
Every result carries a reliability score. 92% confidence from 3 clinical studies hits differently than 40% from anecdotal reports. Your users deserve that distinction.
"Avoid combination" is not medical guidance. We provide washout periods, emergency protocols, and harm reduction strategies. Context that saves lives.
Five severity tiers from synergistic to lethal. Because the difference between "caution" and "contraindicated" matters when you're building safety infrastructure.
PubMed IDs, clinical trial references, and evidence grading on every result. Your compliance team will thank you.
Psychedelics, research chemicals, prescription drugs, supplements. From psilocybin to SSRIs. The pharmacological graph most APIs don't touch.
Use Cases
Give users real-time interaction checks with mechanism-level explanations. Not just "avoid" — but why, and what to do if exposure occurs.
Festival safety apps, drug checking services, peer support platforms
Catch dangerous combinations before they reach patients. Automated screening with confidence scores that map to clinical decision thresholds.
Psychiatric prescribing tools, medication review systems
Access structured pharmacology data at scale. Receptor profiles, mechanism pathways, and interaction matrices for computational analysis.
Drug discovery, pharmacovigilance, clinical trial design
Screen for contraindications in ketamine, psilocybin, and MDMA therapy workflows. Confidence-scored alerts that integrate into clinical intake forms.
Ketamine clinics, psilocybin therapy protocols, MDMA-assisted therapy
For Developers
JSON in, JSON out. No SDK required. Works with any language. First 100 requests free — no credit card.
curl -X POST https://synapedia.com/api/v1/interaction-check \
-H "Authorization: Bearer syn_dk_yourkey" \
-H "Content-Type: application/json" \
-d '{
"substances": ["mdma", "sertraline"],
"include_mechanisms": true,
"include_mitigation": true
}'{
"pair": ["MDMA", "Sertralin (SSRI)"],
"severity": "high",
"confidence": {
"score": 92,
"level": "high",
"sources_count": 3
},
"mechanism": {
"primary": "serotonin_excess",
"detail": "MDMA triggers massive 5-HT release via SERT reversal...",
"pathway": "5-HT2A / SERT",
"receptor_overlap": ["SERT", "5-HT2A", "5-HT1A"]
},
"risk_summary": "Serotonin syndrome — potentially fatal.",
"mitigation": [
"Discontinue SSRI ≥5 half-lives before exposure",
"If symptoms: benzodiazepines, active cooling, emergency care",
"No safe dose exists for this combination"
],
"sources": [
{ "pmid": "18569100", "title": "Serotonin syndrome..." },
{ "pmid": "22475668", "title": "MDMA pharmacology..." }
]
}Available Endpoints
Base URL: https://synapedia.com/api/v1
/interaction-check/substances/:slug/substances?q=query/substances/:slug/interactions/substances/:slug/receptorsPricing
Free tier includes severity + confidence on every request. You're paying for depth — mechanism data, sources, and bulk access.
Evaluate the API. No credit card.
Ship to real users. Full interaction intelligence.
Clinical-grade data for production workloads.
| Data Field | Free | Pro | Business |
|---|---|---|---|
| Severity + summary | |||
| Confidence scoring | |||
| Source count | |||
| Mechanism pharmacology | |||
| PubMed source URLs | |||
| Last reviewed date | |||
| Receptor binding profiles | |||
| Bulk interaction matrix | |||
| Knowledge graph | |||
| Webhook alerts | |||
| Requests / month | 1,000 | 10,000 | 100,000 |
Enterprise plans start at $500/month. Unlimited requests, HIPAA-ready deployment, custom SLAs, and a dedicated account manager.
Contact sales for Enterprise pricingShip real pharmacological intelligence. Mechanism data, confidence scores, and mitigation steps — in every API response.
100 free requests / month · No credit card · JSON REST API
Synapedia provides scientific information only. Not a substitute for medical advice. Use at your own responsibility. All interaction data is based on published pharmacological research.