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Sertraline

Sertraline is a selective serotonin reuptake inhibitor primarily used for the treatment of depression and anxiety disorders. It increases the availability of serotonin in the synaptic cleft by inhibiting the serotonin transporter. The substance has a moderate side effect profile and is frequently prescribed due to its efficacy and tolerability.

Antidepressiva
Antidepressiva
Serotonintransporter (SERT)
5-HT1A-Rezeptor

Mechanism of Action

  • SERT inhibitor
Detailed mechanism of action

Names / Identifiers

IUPAC: Sertraline

sertraline
79617-96-2
(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine
(+)-Sertraline
Sertralina
Sertralinum
cis-(+)-sertraline
Cp 51974
(1S,4S)-sertraline
QUC7NX6WMB

Mechanism of Action

Sertraline wirkt als selektiver Serotonin-Wiederaufnahmehemmer (SSRI), indem es die Wiederaufnahme von Serotonin in die präsynaptischen Neuronen hemmt, was zu einer erhöhten Verfügbarkeit von Serotonin im synaptischen Spalt führt.

Effects

Antidepressiv
Angstlösend
Stimmungsaufhellend
Anxiolytisch
Weniger Schlafstörungen
Verbesserung der Lebensqualität

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-4 weeks
NotesThe effect may build up over several weeks.
Onset1-2 weeks
Total24 hours
After Effectsunknown

Risks & Warnings

Warnings

  • Allergy to sertraline
  • severe liver disease

Known Risks

  • medium
  • Mögliche Nebenwirkungen umfassen Übelkeit, Schlaflosigkeit und sexuelle Dysfunktion.

Safer Use

  • Slow dose adjustment to minimize side effects.
  • Regular medical monitoring.

Harm reduction tips do not replace medical advice.

Known Interactions

  • MAO inhibitors
  • other SSRIs
  • anticoagulants

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USVerschreibungspflichtig
NotesSertraline ist in vielen Ländern als Medikament zur Behandlung von Depressionen und Angststörungen zugelassen.

Not legal advice. Status may change.