Laden…
High Risk: Serotonin syndrome risk from combined serotonergic action
MDMA causes a large release of serotonin via the serotonin transporter (SERT), while SSRIs block the same transporter. Taking them together can lead to an uncontrolled rise in synaptic serotonin and raises the risk of serotonin syndrome, which can present with high body temperature, neuromuscular overactivity and autonomic instability. SSRIs may also blunt the subjective effects of MDMA.
Mechanism data is language-neutral pharmacological notation.
Both substances bind to the following receptors, increasing the risk of pharmacological interactions.
This page is based on curated pharmacological data and/or community signals. It is intended for scientific education and harm reduction only. It does not replace professional medical advice. Not all interactions are covered — always consult a healthcare professional when in doubt. In emergencies, call your local emergency number.