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Moclobemide

Moclobemide is a reversible selective inhibitor of monoamine oxidase A (MAO-A), primarily used for the treatment of depression. It increases the concentration of monoamines such as serotonin, norepinephrine, and dopamine in the synaptic cleft without causing irreversible enzyme inhibition. Due to its reversible action, the risk of severe side effects and interactions is lower than with classical irreversible MAO inhibitors. Nevertheless, interactions with certain foods and medications are possible, which is why caution is advised.

Antidepressivum

Mechanism of Action

Names / Identifiers

IUPAC: Moclobemide

moclobemide
71320-77-9
Aurorix
Moclobemid
Manerix
Moclobemida
Moclobemidum
Moclamine
p-Chloro-N-(2-morpholinoethyl)benzamide
4-Chlor-N-(2-morpholinoethyl)benzamid

Effects

Antidepressiv
Angstlösend
Stimmungsaufhellend
Energiesteigernd
Appetitanregend

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak4-6 weeks
NotesEffect may vary from person to person.
Onset1-2 weeks
Total24 hours
After Effectsunknown

Risks & Warnings

Warnings

  • Severe liver disease
  • Allergy to moclobemide

Known Risks

  • medium
  • Moclobemid kann Wechselwirkungen mit anderen Medikamenten haben und sollte mit Vorsicht angewendet werden.

Safer Use

  • Avoid tyramine-containing foods during use.
  • Regular medical check-ups.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Selective serotonin reuptake inhibitors (SSRIs)
  • Tricyclic antidepressants

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USNicht zugelassen
NotesIn Deutschland und Österreich ist Moclobemid als Antidepressivum zugelassen. In den USA ist es nicht zugelassen.

Not legal advice. Status may change.