Laden…
High Risk: Serotonin syndrome risk from combined serotonergic action
Tramadol has serotonergic activity in addition to its opioid effects, and SSRIs increase serotonin availability by blocking its reuptake. Used together they can raise synaptic serotonin to levels associated with serotonin syndrome, which can present with agitation, muscle twitching, tremor, high body temperature and autonomic instability.
Mechanism data is language-neutral pharmacological notation.
Both substances bind to the following receptors, increasing the risk of pharmacological interactions.
This page is based on curated pharmacological data and/or community signals. It is intended for scientific education and harm reduction only. It does not replace professional medical advice. Not all interactions are covered — always consult a healthcare professional when in doubt. In emergencies, call your local emergency number.