(1-methyl-2-phenyl-ethyl)amine
Amphetamine is a psychoactive stimulant that is commonly used to treat attention deficit hyperactivity disorder (ADHD) and narcolepsy. It increases the concentration of neurotransmitters in the brain, leading to enhanced alertness and energy.
Class
Stimulants
Pharmacological context
Mechanism
Amphetamine acts by inhibiting the reuptake of dopamine and...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
High Risk
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: (1-methyl-2-phenyl-ethyl)amine
Synapedia Evidence
Frequently checked combinations
Amphetamine acts by inhibiting the reuptake of dopamine and norepinephrine and promoting their release from presynaptic neurons. This results in an increased concentration of these neurotransmitters in the synaptic cleft.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 10–30 mg
Total duration 4–8 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–30 mg |
| Strong | 30–60 mg |
Nasal
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–20 mg |
| Strong | 20–40 mg |
IV
| Tier | Dosage |
|---|---|
| Light | 5–10 mg |
| Reported | 10–20 mg |
| Strong | 20–40 mg |
Onset
30–60 minutes
Peak
2–3 hours
Total duration
4–8 hours
After effects
1–3 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Overdose Risk
Hyperthermie, Herzrhythmusstörungen und intrazerebrale Blutungen sind die Haupttodesursachen. Keine spezifische Antidottherapie. Sofortmaßnahmen: Kühlung, Benzodiazepine gegen Agitation und Krampfanfälle. Betablocker nur mit Vorsicht wegen möglicher paradoxer α-vermittelter Vasokonstriktion.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Community summaries. Not consumption guidance.
Report: (DOC/ 5.4 mg /first time) “If you can’t laugh at life, it just isn’t funny anymore.”’
Experiences + discussions about Amphetamin
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Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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