Laden…
O-DSMT (O-desmethyltramadol, desmetramadol) is tramadol's active opioid M1 metabolite and also appears as a standalone research-chemical context. The most reliable framing is mu-opioid receptor activity with risks of respiratory depression, sedation, tolerance, dependence and withdrawal. The tramadol CYP2D6/M1 pathway matters, but O-DSMT should not be treated as ordinary tramadol with transferable dosing rules. The central harm-reduction warning is respiratory depression, loss of consciousness, aspiration and death, especially when combined with benzodiazepines, alcohol, GHB/GBL, gabapentin/pregabalin, other opioids, sedating antihistamines or Z-drugs. Krypton case reports involving mitragynine plus O-desmethyltramadol show that kratom/opioid contexts can become dangerous.
Class
Opioide
Pharmacological context
Mechanism
mu-Opioid-Rezeptor-Aktivitaet als zentraler mechanism of action von...
Short read on known pharmacology
Interactions
3 documented
Curated visible combinations
Risk theme
3 high-risk interactions
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
O-DSMT acts through the following pharmacological mechanisms:
Designations
Synapedia Evidence
Frequently checked combinations
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Dosage & Duration translation in progress
English prose is being expanded. The German version currently has more detail.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks & Harm Reduction translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
Depressant-risk context
This substance belongs to a context where combinations with opioids, benzodiazepines, alcohol, GHB/GBL, or other sedating substances can increase sedation, blackout, aspiration, and breathing-risk patterns. Risk Check can review warning patterns; it is not medical advice and it cannot clear a combination as safe.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some entries are partly based on pharmacological classes. They are useful safety signals, but not fully substance-specific validation.
Some combinations can be dangerous. Research before combining substances. For breathing problems, unconsciousness, seizures, chest pain, high fever, or severe confusion, contact emergency services.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
Effects that O-DSMT shares with related substances.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
Share a report, observation, or question about this substance. Entries are reviewed before publication and marked as unverified community signals.
These entries are submitted by users and are not verified. They may contain subjective experiences, observations, source leads, or corrections. They do not replace scientific data and are not consumption advice.
The signal hub collects approved risk signals, experience reports and source leads by relevance.