Translated automatically – community improvements welcome.
Buprenorphin
Buprenorphine is a semi-synthetic opioid with partial agonist activity at the μ-opioid receptor and antagonism at the κ-opioid receptor. It is primarily used for the treatment of pain and in opioid substitution therapy. Due to its pharmacological properties, it has a lower risk of respiratory depression compared to full agonists, but still carries potential for dependence and abuse.
Mechanism of Action
- κ-opioid receptor antagonist
- μ-opioid receptor partial agonist
Names / Identifiers
IUPAC: (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1S)-1-hydroxy-1,2,2-trimethyl-propyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]eicosa-8(20),9,11-trien-11-ol
Mechanism of Action
Buprenorphine acts as a partial agonist at the μ-opioid receptor, leading to analgesic effects, while simultaneously acting as an antagonist at the κ-opioid receptor, which reduces some of the undesirable effects of opioids. This results in a lower risk of respiratory depression compared to full agonists.
Effects
Effects described from scientific sources. Individual experiences vary.
Dosage
Individual sensitivity varies. Not a dosage recommendation.
Duration
Risks & Warnings
Warnings
- Severe respiratory insufficiency
- Acute withdrawal symptoms
- Allergy to buprenorphine
Known Risks
- medium
- Buprenorphin kann abhängig machen und hat das Potenzial für Missbrauch.
Safer Use
- Start at low doses.
- Regular medical check-ups.
- Avoid concurrent use with other opioids.
Harm reduction tips do not replace medical advice.
Known Interactions
- Benzodiazepines
- Alcohol
- other opioids
This list is not exhaustive. Interactions can have unpredictable effects.
Legal Status
Not legal advice. Status may change.
Entdecken
Ähnliche Substanzen
Basierend auf Substanzklasse, Rezeptoren, Wirkmechanismen und Wirkprofil.