Laden…
(1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]icosa-8(20),9,11-trien-11-ol
Buprenorphine is a semi-synthetic opioid with partial agonist activity at the μ-opioid receptor and antagonism at the κ-opioid receptor. It is primarily used for the treatment of pain and in opioid substitution therapy. Due to its pharmacological properties, it has a lower risk of respiratory depression compared to full agonists, but still carries potential for dependence and abuse.
Receptor Targets
Mechanism of Action
Designations
IUPAC: (1S,2S,6R,14R,15R,16R)-5-(cyclopropylmethyl)-16-[(1S)-1-hydroxy-1,2,2-trimethyl-propyl]-15-methoxy-13-oxa-5-azahexacyclo[13.2.2.12,8.01,6.02,14.012,20]eicosa-8(20),9,11-trien-11-ol
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der κ-Opioid-Rezeptor (KOR) ist ein Gi-coupled GPCR, der Dysphorie, Sedierung und dissoziative Effekte vermitteln kann. Er wird mit Stress- und Suchtmechanismen in Verbindung gebracht.
The μ-opioid receptor (MOR) is a Gi-coupled GPCR involved in analgesia, euphoria and respiratory depression. It is the primary receptor target of most clinically used opioids.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Synapedia Evidence
Buprenorphine acts as a partial agonist at the μ-opioid receptor, leading to analgesic effects, while simultaneously acting as an antagonist at the κ-opioid receptor, which reduces some of the undesirable effects of opioids. This results in a lower risk of respiratory depression compared to full agonists.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 6-12 hours
Peak
1-3 hours
Onset
15-30 minutes
Total duration
6-12 hours
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
strong
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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