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5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene
Mirtazapine is a noradrenergic and specifically serotonergic antidepressant that primarily acts through antagonism at α2-adrenergic receptors and various serotonin receptors. It is commonly used for the treatment of depression and sleep disorders and is characterized by sedating effects. The substance affects multiple neurotransmitter systems, leading to a complex effect profile. Adverse effects may include drowsiness and weight gain.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Mirtazapine acts through the following pharmacological mechanisms:
Designations
IUPAC: 5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der 5-HT2A-Rezeptor ist ein Serotonin-Rezeptor der Klasse Gq-gekoppelter GPCRs. Er ist der primäre molekulare Angriffspunkt klassischer Psychedelika und spielt eine Rolle bei Kognition und Wahrnehmung.
Der Serotonintransporter (SERT/5-HTT) ist ein Natrium-abhängiger Monoamintransporter, der Serotonin aus dem synaptischen Spalt zurück in die präsynaptische Zelle transportiert. Er ist das primäre Ziel von SSRI und MDMA.
Der Noradrenalintransporter (NET) ist ein Monoamintransporter, der Noradrenalin aus dem synaptischen Spalt zurücktransportiert. Er wird von verschiedenen Stimulanzien und Antidepressiva beeinflusst.
Der H1-Rezeptor ist ein Gq/11-gekoppelter Histaminrezeptor, der an allergischen Reaktionen, Wachheit und Thermoregulation beteiligt ist. Antagonismus verursacht Sedierung und wird therapeutisch als Schlafhilfe und Antiallergikum genutzt.
Synapedia Evidence
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 24 hours
Peak
4-6 hours
Onset
1-2 hours
Total duration
24 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Sedierung, Gewichtszunahme und Veränderungen im Blutbild.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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