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[2-(1,3-benzodioxol-5-yl)-1-methyl-ethyl]amine
MDA is a psychoactive empathogen from the phenethylamine class, primarily acting through the release of serotonin, dopamine, and norepinephrine. It produces empathogenic, stimulating, and mildly psychedelic effects. The substance is pharmacologically classified as an entactogen and has a moderate risk profile, particularly due to potential cardiovascular and neurotoxic effects with improper use.
Class
Empathogens
Pharmacological context
Mechanism
MDA (3,4-Methylenedioxyamphetamin) ist ein Entaktogen mit stärkerem...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: [2-(1,3-benzodioxol-5-yl)-1-methyl-ethyl]amine
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
MDA (3,4-Methylenedioxyamphetamin) ist ein Entaktogen mit stärkerem Amphetamine-Charakter als MDMA. MDA wirkt als Substrat-Typ-Releasor an SERT, NET und DAT: Es verdrängt Monoamine aus Vesikeln via VMAT2 und induziert Reverse-Transport. Gegenüber MDMA: MDA zeigt weniger SERT-Selektivität, stärkere DAT-Aktivierung und ist ein partieller 5-HT2A-Agonist — dadurch stärker psychedelisch. Halbwertszeit 5-7h ist länger als MDMA (3-5h), was die längere Gesamtdauer erklärt.
Reported range 100–150 mg
Total duration 6–8 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 50–100 mg |
| Reported | 100–150 mg |
| Strong | 150–200 mg |
Oral
Onset
30–60 minutes
Peak
2–3 hours
Total duration
6–8 hours
After effects
2–4 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Neurotoxicity
possible
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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