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5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one
Toloxatone is a reversible selective monoamine oxidase A inhibitor (RIMA) used for the treatment of depression. It increases the concentration of monoamines such as serotonin and norepinephrine in the synaptic cleft by inhibiting their degradation. Due to its reversible action, it has a lower risk of hypertensive crises compared to irreversible MAO inhibitors. The substance is pharmacologically used for mood enhancement but requires caution when taken concurrently with other serotonergic substances.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Toloxatone acts through the following pharmacological mechanisms:
Designations
IUPAC: 5-methylol-3-(m-tolyl)oxazolidin-2-one
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 12-24 hours
Peak
4-6 hours
Onset
1-2 hours
Total duration
12-24 hours
After effects
Variable
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen und Wechselwirkungen mit anderen Medikamenten.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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