Synapedia

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Toloxatone

Toloxatone is a reversible selective monoamine oxidase A inhibitor (RIMA) used for the treatment of depression. It increases the concentration of monoamines such as serotonin and norepinephrine in the synaptic cleft by inhibiting their degradation. Due to its reversible action, it has a lower risk of hypertensive crises compared to irreversible MAO inhibitors. The substance is pharmacologically used for mood enhancement but requires caution when taken concurrently with other serotonergic substances.

Antidepressiva

Mechanism of Action

Names / Identifiers

IUPAC: Toloxatone

Toloxatone
29218-27-7
Humoryl
Perenum
Toloxatona
Toloxatonum
Taloxotone
Delalande 69276
5-(Hydroxymethyl)-3-(3-methylphenyl)-2-oxazolidinone
5-Hydroxymethyl-3-(m-tolyl)-2-oxazolidinone

Effects

Antidepressiv
Angstlösend
Stimmungsaufhellend
Appetitanregend
Sedierend

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteConsider individual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak4-6 hours
NotesEffect may vary depending on individual metabolism.
Onset1-2 hours
Total12-24 hours
After EffectsVariable

Risks & Warnings

Warnings

  • Severe liver disease
  • Concurrent use of MAO inhibitors

Known Risks

  • medium
  • Mögliche Nebenwirkungen und Wechselwirkungen mit anderen Medikamenten.

Safer Use

  • Start at a low dose.
  • Regular medical supervision.
  • Avoid alcohol and other drugs.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Selective serotonin reuptake inhibitors
  • Tricyclic antidepressants

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATRezeptpflichtig
CHRezeptpflichtig
DERezeptpflichtig
USRezeptpflichtig
NotesToloxatone ist in vielen Ländern als Antidepressivum zugelassen und unterliegt daher strengen Regulierungen.

Not legal advice. Status may change.