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5-Methoxy-DMT is a substance from the class of tryptamines. Further information will follow after enrichment.
Class
Psychedelika
Pharmacological context
Mechanism
5-Methoxy-N,N-Dimethyltryptamin (5-MeO-DMT) unterscheidet sich von...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Designations
IUPAC: 5-Methoxy-DMT
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der Sigma-1-Rezeptor ist ein einzigartiges Chaperon-Protein im endoplasmatischen Retikulum, das Calciumsignale und Proteinfaltung moduliert. Er wird nicht-klassisch als GPCR-ähnlich eingeordnet und hat Bindungsstellen für verschiedene Psychoaktiva.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
5-Methoxy-N,N-Dimethyltryptamin (5-MeO-DMT) unterscheidet sich von N,N-DMT fundamental: Es wirkt primär als vollständiger Agonist am 5-HT1A-Rezeptor (nicht 5-HT2A wie DMT). Diese 5-HT1A-Dominanz erklärt die charakteristische nicht-visuelle, überwältigend ego-auflösende Qualität. 5-MeO-DMT agonisiert auch 5-HT2A und 5-HT2C, aber mit deutlich geringerer Potenz als N,N-DMT. Der SERT ist ein Substrat, das zu schneller Metabolisierung durch MAO-A und MAO-B führt. Die 5-HT1A-Agonismus-dominierte Psychopharmakologie führt zum charakteristischen „White-Out"-Phänomen und mystischen Zustandserlebnis.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 3–5 mg
Total duration 4–6 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 1–3 mg |
| Reported | 3–5 mg |
| Strong | 5–10 mg |
Geraucht
| Tier | Dosage |
|---|---|
| Light | 1–2 mg |
| Reported | 2–5 mg |
| Strong | 5–10 mg |
Onset
20–60 minutes
Peak
1–2 hours
Total duration
4–6 hours
After effects
1–3 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
limited
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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