Laden…
GBL is a precursor to GHB and acts as a sedative by activating GHB and GABA-B receptors. It has a high potential for abuse and dependence, as well as a significant risk for overdose and respiratory depression. The substance is pharmacologically classified as a central depressant and can lead to loss of consciousness.
Class
Depressiva
Pharmacological context
Mechanism
GBL is metabolized in the body to GHB, which acts as an agonist at GABA...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
High Risk
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: tetrahydrofuran-2-one
Receptor Profile
Der GABA-B-Rezeptor ist ein Gi/Go-gekoppelter metabotroper GABA-Rezeptor, der als Heterodimer (GABA-B1/B2) funktioniert. Er moduliert die Neurotransmitterfreisetzung und vermittelt langsame inhibitorische postsynaptische Potenziale.
Synapedia Evidence
GBL is metabolized in the body to GHB, which acts as an agonist at GABA receptors. This leads to a depressant effect on the central nervous system.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 1–2 g
Total duration 3–4 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 0.5–1 g |
| Reported | 1–2 g |
| Strong | 2–4 g |
Oral
Onset
15–30 minutes
Peak
1–2 hours
Total duration
3–4 hours
After effects
1–2 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Hohes Missbrauchs- und Abhängigkeitspotential, Risiko für Überdosierung und Atemdepression.
Safer Use
Depressant-risk context
This substance belongs to a context where combinations with opioids, benzodiazepines, alcohol, GHB/GBL, or other sedating substances can increase sedation, blackout, aspiration, and breathing-risk patterns. Risk Check can review warning patterns; it is not medical advice and it cannot clear a combination as safe.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Experiences + discussions about GBL
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Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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