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Opipramol

Opipramol is a tricyclic antidepressant with anxiolytic and sedative properties. It primarily acts by blocking Sigma-1 receptors as well as antagonistically at histamine, dopamine, and serotonin receptors. The substance is mainly used for the treatment of anxiety disorders and depressive symptoms. Due to its mode of action, it may lead to sedative effects and other side effects, which is why medical supervision is recommended.

Antidepressiva
Antidepressiva
Sigma-1-Rezeptoren
Histaminrezeptoren
Dopaminrezeptoren
Serotoninrezeptoren

Mechanism of Action

  • 5-HT2A antagonist
  • D2 receptor antagonist
  • H1 receptor antagonist
  • Sigma-1 receptor antagonist
Detailed mechanism of action

Names / Identifiers

IUPAC: Opipramol

Opipramol
315-72-0
Opipramolum
Opipramol dura
2-[4-(3-benzo[b][1]benzazepin-11-ylpropyl)piperazin-1-yl]ethanol
1-Piperazineethanol, 4-[3-(5H-dibenz[b,f]azepin-5-yl)propyl]-
NSC-169867
D23ZXO613C
4-(3-(5H-Dibenz(b,f)azepin-5-yl)propyl)-1-piperazineethanol
4-[3-(5H-Dibenz[b,f]azepin-5-yl)propyl]-1-piperazineethanol

Mechanism of Action

Opipramol wirkt als ein atypisches Antidepressivum, das die Wiederaufnahme von Serotonin und Noradrenalin hemmt und zusätzlich eine modulierende Wirkung auf die Rezeptoren hat.

Effects

anxiolytisch
antidepressiv
sedierend
stimmungsaufhellend
muskelrelaxierend
antipsychotisch

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak4-6 hours
NotesEffects may last different lengths of time in different individuals.
Onset1-2 hours
Total24 hours
After EffectsVariable

Risks & Warnings

Warnings

  • Pregnancy
  • Breastfeeding
  • severe liver or kidney diseases

Known Risks

  • medium
  • Mögliche Nebenwirkungen umfassen Schläfrigkeit, Mundtrockenheit und Gewichtszunahme.

Safer Use

  • Start at a low dose.
  • Regular medical check-ups.
  • Be aware of interactions with other medications.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Alcohol
  • Benzodiazepines
  • other antidepressants

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USVerschreibungspflichtig
NotesIn vielen Ländern ist Opipramol nur auf Rezept erhältlich.

Not legal advice. Status may change.