Synapedia

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Trazodone

Trazodone is an atypical antidepressant with sedative properties that primarily acts as a serotonin reuptake inhibitor and 5-HT2A antagonist. It is commonly used for the treatment of depression and sleep disorders. Side effects may include drowsiness and orthostatic hypotension. The substance has a moderate risk profile, particularly when combined with other central depressants.

Antidepressiva
Antidepressiva
5-HT2A-Rezeptor
5-HT1A-Rezeptor
α1-Adrenozeptor
Histamin H1-Rezeptor

Mechanism of Action

  • 5-HT2A antagonist
  • SERT inhibitor

Names / Identifiers

IUPAC: Trazodone

trazodone
19794-93-5
Trazodon
Beneficat
Trazalon
Trazodil
Trazodona
Trazonil
Trittico
Desirel

Mechanism of Action

Trazodon wirkt hauptsächlich als Serotonin-Wiederaufnahmehemmer und Antagonist am 5-HT2A-Rezeptor, was zu einer Erhöhung der Serotoninverfügbarkeit im synaptischen Spalt führt.

Effects

Sedierung
Antidepressiv
Angstlindernd
Schlaffördernd
Anxiolytisch
Stimmungsaufhellend

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak3-6 hours
NotesEffect may vary depending on individual metabolism.
Onset1-2 hours
Total24 hours
After EffectsUp to 24 hours

Risks & Warnings

Warnings

  • Acute liver disease
  • Pregnancy
  • Breastfeeding

Known Risks

  • medium
  • Mögliche Nebenwirkungen sind Schläfrigkeit, Schwindel und Mundtrockenheit.

Safer Use

  • Start at a low dose.
  • Consider regular medical monitoring.

Harm reduction tips do not replace medical advice.

Known Interactions

  • MAO inhibitors
  • Alcohol
  • other antidepressants

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USVerschreibungspflichtig
NotesTrazodon ist in vielen Ländern als Antidepressivum zugelassen.

Not legal advice. Status may change.

Entdecken

Ähnliche Substanzen

Basierend auf Substanzklasse, Rezeptoren, Wirkmechanismen und Wirkprofil.

Gemeinsame Wirkungsmuster

Wirkungen, die Trazodone mit verwandten Substanzen teilt.

sedierung
auch beiKratom