Synapedia

Translated automatically – community improvements welcome.

AD-810

Zonisamide is an anticonvulsant primarily used for the treatment of epilepsy. It acts by blocking voltage-gated sodium channels and inhibiting T-type calcium channels, which reduces neuronal excitability. Additionally, it modulates neurotransmitters such as dopamine and serotonin. The substance has neuroprotective properties and is occasionally used off-label for other neurological disorders.

Antiepileptikum
Antidepressiva
Natriumkanäle
Calciumkanäle
GABA-Rezeptoren

Mechanism of Action

  • Na+ channel blocker
  • T-type Ca2+ channel inhibitor

Names / Identifiers

IUPAC: Zonisamide

zonisamide
68291-97-4
Zonegran
1,2-Benzisoxazole-3-methanesulfonamide
1,2-benzoxazol-3-ylmethanesulfonamide
Exceglan
Excegram
Excegran
AD-810
Zonisamida

Mechanism of Action

Zonisamid wirkt hauptsächlich durch die Hemmung von spannungsabhängigen Natriumkanälen und die Modulation von Calciumkanälen, was zu einer Stabilisierung der neuronalen Erregbarkeit führt.

Effects

antikonvulsiv
schmerzlindernd
stimmungsaufhellend
neuroprotektiv
muskelrelaxierend

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-6 hours
NotesEffect may vary depending on individual metabolism.
Onset1-2 hours
Total24 hours
After EffectsVariable

Risks & Warnings

Warnings

  • Allergy to zonisamide or related substances.
  • Pregnancy and breastfeeding without medical supervision.

Known Risks

  • medium
  • Mögliche Nebenwirkungen umfassen Schwindel, Müdigkeit und Hautausschläge.

Safer Use

  • Start at a low dose.
  • Conduct regular medical check-ups.

Harm reduction tips do not replace medical advice.

Known Interactions

  • May interact with other antiepileptics.
  • Interactions with certain antidepressants possible.

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USVerschreibungspflichtig
NotesZonisamid ist in vielen Ländern als Antiepileptikum zugelassen.

Not legal advice. Status may change.