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St. John's Wort (Hypericum perforatum) is a herbal preparation primarily used for the treatment of mild to moderate depression. It mainly acts by inhibiting the reuptake of neurotransmitters such as serotonin, norepinephrine, and dopamine. Additionally, it modulates GABA and glutamate receptors, contributing to a mood-enhancing effect. Caution is advised due to interactions with other medications.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Designations
IUPAC: St. John's Wort (Hypericum)
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration Long-term
Peak
4-6 weeks
Onset
1-2 weeks
Total duration
Long-term
After effects
Variable
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Kann Wechselwirkungen mit anderen Medikamenten haben und sollte mit Vorsicht verwendet werden.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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