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cis-(1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide
Levomilnacipran is a selective serotonin-norepinephrine reuptake inhibitor (SNRI) used for the treatment of depression. It works by inhibiting the reuptake of serotonin and norepinephrine, which increases the availability of these neurotransmitters in the synaptic cleft. The substance has a moderate side effect profile and is frequently prescribed for major depression. Due to its pharmacological properties, it may have effects on the central nervous system and the cardiovascular system.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Levomilnacipran acts through the following pharmacological mechanisms:
Designations
IUPAC: cis-(1S,2R)-2-(aminomethyl)-N,N-diethyl-1-phenyl-cyclopropanecarboxamide
Receptor Profile
Der Serotonintransporter (SERT/5-HTT) ist ein Natrium-abhängiger Monoamintransporter, der Serotonin aus dem synaptischen Spalt zurück in die präsynaptische Zelle transportiert. Er ist das primäre Ziel von SSRI und MDMA.
Der Noradrenalintransporter (NET) ist ein Monoamintransporter, der Noradrenalin aus dem synaptischen Spalt zurücktransportiert. Er wird von verschiedenen Stimulanzien und Antidepressiva beeinflusst.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Synapedia Evidence
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 24 hours
Peak
4-6 hours
Onset
1-2 weeks
Total duration
24 hours
After effects
unknown
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Übelkeit, Schwindel und Schlaflosigkeit.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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