Laden…
2-[(E)-2-cyclohexa-1,5-dien-1-ylvinyl]-4-methoxy-2,3-dihydropyran-6-one
Class
Depressiva
Pharmacological context
Mechanism
Dopaminergic Activity, GABA-A Modulation
Short read on known pharmacology
Interactions
2 documented
Curated visible combinations
Risk theme
1 high-risk interaction
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Mechanism of Action
Kava acts through the following pharmacological mechanisms:
Designations
IUPAC: 2-[(E)-2-cyclohexa-1,5-dien-1-ylvinyl]-4-methoxy-2,3-dihydropyran-6-one
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Reported range 100–250 mg kavalactones
Total duration 4–6 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 50–100 mg kavalactones |
| Reported | 100–250 mg kavalactones |
| Strong | 250–500 mg kavalactones |
Oral
Onset
30–60 minutes
Peak
1–2 hours
Total duration
4–6 hours
After effects
1–2 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Lebertoxizität bei übermäßigem Konsum. Wechselwirkungen mit Alkohol und anderen Sedativa.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Some entries are pharmacological class warnings. They are useful safety signals, but not substance-specific clinical validation.
Some combinations can be dangerous. Research before combining substances. For breathing problems, unconsciousness, seizures, chest pain, high fever, or severe confusion, contact emergency services.
Dangerous interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Caution-level interaction risk
Detailed interaction narrative is still being translated. This row shows the available risk level and data provenance only.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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