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Tolcapone

Tolcapone is a selective and reversible inhibitor of the enzyme catechol-O-methyltransferase (COMT), used in the treatment of Parkinson's disease. It enhances dopaminergic neurotransmission by inhibiting dopamine degradation. Due to potential hepatotoxic effects, careful monitoring of liver function is required. Tolcapone is used as an adjunct to L-Dopa therapy to alleviate motor symptoms.

Antidepressiva
Antidepressiva
COMT

Mechanism of Action

  • COMT inhibitor
Detailed mechanism of action

Names / Identifiers

IUPAC: Tolcapone

Tolcapone
134308-13-7
Tasmar
3,4-Dihydroxy-4'-methyl-5-nitrobenzophenone
Ro 40-7592
(3,4-Dihydroxy-5-nitrophenyl)(4-methylphenyl)methanone
Ro-40-7592
(3,4-dihydroxy-5-nitrophenyl)-(4-methylphenyl)methanone
Methanone, (3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-
Tolcapona

Mechanism of Action

Tolcapone wirkt als Hemmer des Enzyms Catechol-O-Methyltransferase (COMT), was zu einer erhöhten Verfügbarkeit von Dopamin im zentralen Nervensystem führt.

Effects

Erhöhung der Dopaminverfügbarkeit
Verbesserung der motorischen Kontrolle
Reduktion von Parkinson-Symptomen
Erhöhung der kognitiven Funktion
Mögliche Verbesserung der Stimmung

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteConsider individual variation, start with a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-4 hours
NotesEffect may vary depending on individual metabolism.
Onset1-2 hours
Total6-8 hours
After EffectsUnknown

Risks & Warnings

Warnings

  • Severe liver diseases.
  • Concurrent use of MAO inhibitors.

Known Risks

  • medium
  • Mögliche Nebenwirkungen umfassen Leberfunktionsstörungen und gastrointestinalen Beschwerden.

Safer Use

  • Conduct regular liver function tests.
  • Watch for symptoms of liver disease.

Harm reduction tips do not replace medical advice.

Known Interactions

  • May interact with MAO inhibitors.
  • Caution with concurrent use of other medications that affect the liver.

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USVerschreibungspflichtig
NotesTolcapone ist in vielen Ländern als Medikament zur Behandlung von Parkinson zugelassen.

Not legal advice. Status may change.

Receptor Targets

COMT

Catechol-O-Methyltransferase (COMT) ist ein Enzym, das Katecholamine (Dopamin, Noradrenalin, Adrenalin) durch Methylierung inaktiviert. Der Val158Met-Polymorphismus beeinflusst die Enzymaktivität und kognitive Funktionen.

enzyme