Laden…
N-[4-(methoxymethyl)-1-(2-thiophen-2-ylethyl)piperidin-4-yl]-N-phenylpropanamide
Sufentanil is a substance from the class of fentanyls. Further information will follow after accumulation.
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Designations
IUPAC: N-[4-(methoxymethyl)-1-[2-(2-thienyl)ethyl]-4-piperidyl]-N-phenyl-propionamide
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Sufentanil ist ein synthetisches Thienylderivat von Fentanyl mit außerordentlich hoher Potenz: ca. 5-10× potenter als Fentanyl und 500-1000× potenter als Morphin. Wie alle μ-Opioid-Agonisten hemmt Sufentanil über Gi-Protein-Kopplung die Adenylylcyclase (↓cAMP), aktiviert einwärtsgleichrichtende K⁺-Kanäle (Hyperpolarisierung) und inhibiert spannungsgesteuerte Ca²⁺-Kanäle. Dies führt zu Analgesie, Sedierung, respiratory depression und Euphorie. Extrem hohe Lipophilie (Oktanol/Wasser-Koeffizient >>Fentanyl) ermöglicht ultraschnelle ZNS-Penetration. Die Kombination aus ultrahöher MOR-Affinität, rapidem ZNS-Eintritt und vollständigem Agonismus ergibt einen marginalen Sicherheitsabstand: Der Unterschied zwischen analgetischer und letaler Dosis ist bei Sufentanil kleiner als bei jedem anderen klinisch verwendeten Opioid. Glattmuskeleffekte: erhebliche Bradykardie, Bronchokonstriktion, Chest-Wall-Rigidity. Vorwiegend in der Anästhesie/Intensivmedizin eingesetzt; Sufentanil-Nasenspray ist die einzige Formulierung mit eingeschränktem Einsatz außerhalb des OP (präklinische Analgesie).
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 2-4 hours
Peak
5-10 minutes
Onset
1-2 minutes
Total duration
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
strong
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
Share a report, observation, or question about this substance. Entries are reviewed before publication and marked as unverified community signals.
These entries are submitted by users and are not verified. They may contain subjective experiences, observations, source leads, or corrections. They do not replace scientific data and are not consumption advice.
The signal hub collects approved risk signals, experience reports and source leads by relevance.