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3-ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
Molindone is a typical antipsychotic that primarily acts as a dopamine D2 receptor antagonist. It is used for the treatment of schizophrenia and additionally affects serotonergic and adrenergic receptors. The substance can cause extrapyramidal side effects and requires careful medical monitoring.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Molindone acts through the following pharmacological mechanisms:
Designations
IUPAC: 3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydroindol-4-one
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der 5-HT2A-Rezeptor ist ein Serotonin-Rezeptor der Klasse Gq-gekoppelter GPCRs. Er ist der primäre molekulare Angriffspunkt klassischer Psychedelika und spielt eine Rolle bei Kognition und Wahrnehmung.
Der D2-Rezeptor ist ein Gi-gekoppelter Dopaminrezeptor mit hoher Dichte im Striatum. Er ist ein wichtiges Ziel für Antipsychotika und moduliert motorische Funktionen sowie Belohnungsverarbeitung.
Der Dopamintransporter (DAT) ist ein Natrium-abhängiger Monoamintransporter, der Dopamin aus dem synaptischen Spalt entfernt. Er ist ein zentrales Ziel von Stimulanzien und spielt eine Schlüsselrolle im Belohnungssystem.
Der 5-HT2C-Rezeptor ist ein Gq/11-gekoppelter Serotoninrezeptor, der an der Regulation von Appetit, Stimmung und Angst beteiligt ist. Er wird von verschiedenen Psychedelika als sekundäres Ziel aktiviert und moduliert dopaminerge Signalwege.
Der α1-adrenerge Rezeptor ist ein Gq/11-gekoppelter GPCR, der Vasokonstriktion, Mydriasis und glatte Muskelkontraktion vermittelt. Er spielt eine zentrale Rolle bei der sympathischen Kreislaufregulation.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Synapedia Evidence
Effects & Pharmacology — Translation in progress
This section is being translated. Content is available in German.
View in German →Total duration 24 hours
Peak
3-6 hours
Onset
1-2 hours
Total duration
24 hours
After effects
Variable
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Kann extrapyramidale Nebenwirkungen verursachen.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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