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N,N-dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide
Zolpidem is a fast-acting hypnotic from the imidazopyridine group, primarily used for the short-term treatment of sleep disorders. It acts as an agonist at the benzodiazepine binding site of the GABA-A receptor, thereby enhancing the inhibitory effect of GABA in the central nervous system. Due to its mechanism of action, it may have potential for dependence and should only be used under medical supervision.
Class
Sedativa
Pharmacological context
Mechanism
Zolpidem ist ein Nicht-Benzodiazepin-Hypnotikum (Z-Drug) und selektiver...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: N,N-dimethyl-2-[6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl]acetamide
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Zolpidem ist ein Nicht-Benzodiazepin-Hypnotikum (Z-Drug) und selektiver positiv-allosterischer Modulator von GABAA-Rezeptoren mit Präferenz für α1-Untereinheiten (Imidazopyridin-Bindungsstelle). Die α1-Selektivität erklärt das primär sedativ-hypnotische Profil mit geringerer Anxiolyse/Antikonvulsion als klassische Benzodiazepine. Bei therapeutischen Dosen (5-10mg) hohe α1-Selektivität. Bei höheren Dosen nimmt die Selektivität ab (α2/α3 mitbetroffen), was Euphorie und missbräuchliche Effekte erklären kann. Kurze Halbwertszeit (2-3h) spezifisch für Einschlafstörungen konzipiert.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 10 mg
Total duration 6–8 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 5 mg |
| Reported | 10 mg |
| Strong | 20 mg |
Oral
Onset
15–30 minutes
Peak
1–2 hours
Total duration
6–8 hours
After effects
2–4 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Evidence
strong
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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