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[(7S)-6-(5-chloro-2-pyridinyl)-5-oxo-7H-pyrrolo[3,4-b]pyrazin-7-yl] 4-methylpiperazine-1-carboxylate
Eszopiclone is a hypnotic sedative from the cyclopyrrolone group, primarily used for the treatment of sleep disorders. It acts as a positive allosteric modulator at the GABA-A receptor, thereby enhancing the inhibitory effect of GABA in the central nervous system. The substance has a relatively short duration of action and is often used to improve sleep onset and maintenance. Adverse effects may include drowsiness and cognitive impairments. The risk for dependence and withdrawal symptoms is moderate.
Receptor Targets
Mechanism of Action
Designations
IUPAC: 4-methylpiperazine-1-carboxylic acid [(7S)-6-(5-chloro-2-pyridyl)-5-keto-7H-pyrrolo[3,4-b]pyrazin-7-yl] ester
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some content may appear in German.
Eszopiclon ist das aktive S-Enantiomer von Racemzopiclon (Zopiclon) und positiv-allosterischer Modulator an GABAA-Rezeptoren an der Benzodiazepinbindungsstelle. Der pharmakologische Wirkmechanismus ist mit Zopiclon identisch, jedoch mit ca. 2× höherer Potenz auf mg-Basis (da Racemzopiclon zur Hälfte aus dem inaktiveren R-Enantiomer besteht). Leichte α1-Subtypen-Bevorzugung (Sedierung, Amnesie) gegenüber α2/α3 (Anxiolyse). Längere Halbwertszeit als Zopiclon (6h vs 5h) und direkterer Metabolisierungsweg. CYP3A4-Substrat. Klinisch wichtig: Eszopiclon hat mit 6mg die höchste FDA-Dosierungszulassung unter Z-Hypnotika, was das Missbrauchs- und Abhängigkeitspotential verstärkt. Eszopiclon verursacht häufig einen persistierenden Dysgeusie (schlechten Nachgeschmack) — häufigster Grund für Therapieabbruch.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 6-8 hours
Peak
1-2 hours
Onset
30 minutes
Total duration
6-8 hours
After effects
Fatigue, drowsiness
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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