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4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
Ropinirole is a non-ergot dopamine agonist primarily used as a therapeutic agent for Parkinson's disease and Restless Legs Syndrome. It acts by stimulating dopamine D2 and D3 receptors, alleviating motor symptoms. Side effects may include nausea, drowsiness, and impulse control disorders. The substance affects the central nervous system and requires careful medical monitoring.
Receptor Targets
Mechanism of Action
Designations
IUPAC: 4-[2-(dipropylamino)ethyl]oxindole
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der 5-HT1A-Rezeptor ist ein Gi/Go-gekoppelter Serotoninrezeptor, der als Autorezeptor auf serotonergen Neuronen und als Heterorezeptor in verschiedenen Hirnregionen vorkommt. Er moduliert Angst, Stimmung und Kognition.
Der D2-Rezeptor ist ein Gi-gekoppelter Dopaminrezeptor mit hoher Dichte im Striatum. Er ist ein wichtiges Ziel für Antipsychotika und moduliert motorische Funktionen sowie Belohnungsverarbeitung.
Der D3-Rezeptor ist ein Gi/Go-gekoppelter Dopaminrezeptor mit hoher Expression in limbischen Regionen. Er moduliert Belohnungsverarbeitung, Motivation und wird mit Suchtverhalten in Verbindung gebracht.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Ropinirole wirkt durch die Stimulation von Dopamin-D2- und D3-Rezeptoren im Gehirn, was zur Linderung motorischer Symptome bei Parkinson-Krankheit und Restless-Legs-Syndrom führt.
Total duration 24 hours
Peak
2-4 hours
Onset
1-2 hours
Total duration
24 hours
After effects
Variable
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Übelkeit, Schwindel und Schlafstörungen.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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