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Rotigotine

Rotigotine is a dopamine agonist primarily used for the treatment of Parkinson's disease and Restless Legs Syndrome. It acts by stimulating dopamine receptors in the brain and is often administered via a transdermal patch. The substance provides continuous dopaminergic stimulation, which can alleviate motor symptoms. Side effects may include nausea, dizziness, and sleep disturbances.

Dopaminagonisten
Stimulanzien
Antidepressiva
Dopaminrezeptoren
D2-Rezeptoren
D3-Rezeptoren

Mechanism of Action

  • D2 receptor agonist
  • D3 receptor agonist
Detailed mechanism of action

Names / Identifiers

IUPAC: Rotigotine

Rotigotine
99755-59-6
Neupro
Leganto
SPM 962
SPM-962
Rotigotina
87T4T8BO2E
DTXSID5046772
(6S)-6-(Propyl(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol

Mechanism of Action

Rotigotine wirkt als Agonist an Dopaminrezeptoren, insbesondere an D2- und D3-Rezeptoren, was zu einer Erhöhung der dopaminergen Aktivität im zentralen Nervensystem führt.

Effects

Erhöhung der motorischen Kontrolle
Verbesserung der Stimmung
Reduktion von Tremor
Steigerung der kognitiven Funktion
Linderung von Parkinson-Symptomen

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak2-4 hours
NotesDuration of action may vary depending on dose and individual metabolism.
Onset30-60 minutes
Total24 hours
After EffectsIndeterminate

Risks & Warnings

Warnings

  • Severe liver disease
  • Allergy to Rotigotine

Known Risks

  • medium
  • Mögliche Nebenwirkungen umfassen Übelkeit, Schwindel und Schlafstörungen.

Safer Use

  • Start at a low dose.
  • Regular medical check-ups.

Harm reduction tips do not replace medical advice.

Known Interactions

  • Antipsychotics
  • Antidepressants

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATVerschreibungspflichtig
CHVerschreibungspflichtig
DEVerschreibungspflichtig
USVerschreibungspflichtig
NotesRotigotine ist in vielen Ländern als Medikament zur Behandlung der Parkinson-Krankheit zugelassen.

Not legal advice. Status may change.