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3-[2-(dimethylamino)ethyl]-1H-indol-4-ol
Psilocin is a psychoactive tryptamine that primarily acts as an active metabolite of psilocybin. It mainly binds to serotonin receptors, particularly 5-HT2A, thereby inducing psychedelic effects. The substance is being investigated in research for consciousness alteration and potential therapeutic applications. Risks primarily involve psychological stress and the possibility of unpleasant experiences.
Receptor Targets
Mechanism of Action
Designations
IUPAC: Psilocin
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Psilocin (4-Hydroxy-N,N-Dimethyltryptamin) ist der aktive Metabolit von Psilocybin und wirkt direkt (ohne Prodrug-Umwandlung) als partieller Agonist am 5-HT2A-Rezeptor – der primäre psychedelische mechanism of action. Zusätzlich agonisiert Psilocin 5-HT2C-, 5-HT1A-, 5-HT1B-, 5-HT1D-, 5-HT6- und 5-HT7-Rezeptoren. Der SERT ist ein schwacher Substrat (Reuptake-Hemmung), aber nicht signifikant im Vergleich zu DMT. Aufgrund der fehlenden Prodrug-Konversions-Stufe im Gastrointestinaltrakt hat Psilocin schnelleren Wirkungseintritt als Psilocybin und ist etwas potenter auf Gewichtsbasis.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 4-6 hours
Peak
1-2 hours
Onset
20-40 minutes
Total duration
4-6 hours
After effects
1-3 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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