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Opium is a natural opioid derived from the dried latex of the opium poppy. It primarily acts as an agonist at various opioid receptors and has analgesic, sedative, and euphoric effects. Due to its high potential for addiction and the risk of respiratory depression, its use is classified as risky. Opium contains several alkaloids, including morphine and codeine, which are responsible for its pharmacological effects.
Receptor Targets
Mechanism of Action
Designations
IUPAC: Opium
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der Serotonintransporter (SERT/5-HTT) ist ein Natrium-abhängiger Monoamintransporter, der Serotonin aus dem synaptischen Spalt zurück in die präsynaptische Zelle transportiert. Er ist das primäre Ziel von SSRI und MDMA.
Der Noradrenalintransporter (NET) ist ein Monoamintransporter, der Noradrenalin aus dem synaptischen Spalt zurücktransportiert. Er wird von verschiedenen Stimulanzien und Antidepressiva beeinflusst.
Der Dopamintransporter (DAT) ist ein Natrium-abhängiger Monoamintransporter, der Dopamin aus dem synaptischen Spalt entfernt. Er ist ein zentrales Ziel von Stimulanzien und spielt eine Schlüsselrolle im Belohnungssystem.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some content may appear in German.
Opium wirkt hauptsächlich durch die Bindung an μ-Opioid-Rezeptoren im zentralen Nervensystem, was zu einer Hemmung der Schmerzübertragung und einer Erhöhung des Schmerztoleranzniveaus führt.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 4-6 hours (oral), 2-4 hours (intravenous), 1-3 hours (smoked)
Peak
1-2 hours (oral), 30 minutes (intravenous), 15-30 minutes (smoked)
Onset
30-60 minutes (oral), 5-10 minutes (intravenous), 5-15 minutes (smoked)
Total duration
4-6 hours (oral), 2-4 hours (intravenous), 1-3 hours (smoked)
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Hohe Suchtgefahr, Atemdepression und Überdosierungsrisiko.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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