Laden…
3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
Nicotine is a potent alkaloid that primarily acts on nicotinic acetylcholine receptors in the central and peripheral nervous systems. It leads to the release of various neurotransmitters, particularly dopamine, which significantly contributes to the development of dependence. Nicotine has stimulating effects and influences cognitive functions as well as the reward system. The substance carries a high potential for addiction and can cause health risks through long-term use.
Receptor Targets
Mechanism of Action
Designations
IUPAC: 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der NMDA-Rezeptor ist ein ionotroper Glutamatrezeptor, der eine zentrale Rolle bei synaptischer Plastizität, Lernen und Gedächtnisbildung spielt. Er benötigt sowohl Glutamat als auch Glycin als Co-Agonisten zur Aktivierung.
Der GABA-A-Rezeptor ist ein ligandengesteuerter Chloridkanal und der wichtigste inhibitorische Rezeptor im zentralen Nervensystem. Er besitzt multiple allosterische Bindungsstellen für verschiedene Substanzklassen.
Der Dopamintransporter (DAT) ist ein Natrium-abhängiger Monoamintransporter, der Dopamin aus dem synaptischen Spalt entfernt. Er ist ein zentrales Ziel von Stimulants und spielt eine Schlüsselrolle im Belohnungssystem.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Nikotin wirkt als Agonist an nikotinischen Acetylcholinrezeptoren, was zur Freisetzung von Neurotransmittern wie Dopamin führt und somit eine Vielzahl von physiologischen Effekten hervorruft.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 1-3 hours
Peak
30-60 minutes
Onset
5-10 minutes
Total duration
1-3 hours
After effects
30-90 minutes
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Hohe Abhängigkeit und gesundheitliche Risiken, insbesondere bei langfristigem Konsum.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
Share a report, observation, or question about this substance. Entries are reviewed before publication and marked as unverified community signals.
These entries are submitted by users and are not verified. They may contain subjective experiences, observations, source leads, or corrections. They do not replace scientific data and are not consumption advice.
The signal hub collects approved risk signals, experience reports and source leads by relevance.