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Substance Comparison
MDA stands out with markedly stronger psychedelic depth. MDA stands out with markedly stronger empathy & warmth. In terms of addiction risk, Mephedron (4-MMC) scores notably higher.
Despite belonging to different classes, these substances share receptor activity at SERT and NET, which may produce overlapping effects.
MDA has significantly higher psychedelic depth
MDA has significantly higher empathy & warmth
Mephedron (4-MMC) has notably higher addiction risk
| MDA | Mephedron (4-MMC) | |
|---|---|---|
| Class | Empathogene | Stimulanzien |
| Risk Level | high | high |
| Mechanisms | SERT-Umkehrtransport, NET-Umkehrtransport, DAT-Umkehrtransport, 5-HT2A-Agonist | SERT-Umkehrtransport, DAT-Umkehrtransport, NET-Umkehrtransport |
| Receptors | SERT, NET, DAT, 5-HT2A | SERT, DAT, NET |
| Effects | — | — |
| Evidence | limited | — |
MDA (3,4-Methylenedioxyamphetamin) ist ein Entaktogen mit stärkerem Amphetamin-Charakter als MDMA. MDA wirkt als Substrat-Typ-Releasor an SERT, NET und DAT: Es verdrängt Monoamine aus Vesikeln via VMAT2 und induziert Reverse-Transport. Gegenüber MDMA: MDA zeigt weniger SERT-Selektivität, stärkere DAT-Aktivierung und ist ein partieller 5-HT2A-Agonist — dadurch stärker psychedelisch. Halbwertszeit 5-7h ist länger als MDMA (3-5h), was die längere Gesamtdauer erklärt.
Safer-use data available on substance page
No harm reduction data available
Evidence: limited · Sources: 4
Evidence: not assessed · Sources: 2