Laden…
Ketamine is a dissociative anesthetic and NMDA receptor antagonist used in clinical anesthesia and being actively investigated as a rapid-acting treatment for treatment-resistant depression. At sub-anesthetic doses it produces dissociative, analgesic, and psychedelic effects.
Class
Dissoziativa
Pharmacological context
Mechanism
NMDA-Antagonist
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Moderate Risk
Condensed from structured notes
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Ketamin acts through the following pharmacological mechanisms:
Receptor Profile
Der NMDA-Rezeptor ist ein ionotroper Glutamatrezeptor, der eine zentrale Rolle bei synaptischer Plastizität, Lernen und Gedächtnisbildung spielt. Er benötigt sowohl Glutamat als auch Glycin als Co-Agonisten zur Aktivierung.
The μ-opioid receptor (MOR) is a Gi-coupled GPCR involved in analgesia, euphoria and respiratory depression. It is the primary receptor target of most clinically used opioids.
Der κ-Opioid-Rezeptor (KOR) ist ein Gi-coupled GPCR, der Dysphorie, Sedierung und dissoziative Effekte vermitteln kann. Er wird mit Stress- und Suchtmechanismen in Verbindung gebracht.
Der D2-Rezeptor ist ein Gi-gekoppelter Dopaminrezeptor mit hoher Dichte im Striatum. Er ist ein wichtiges Ziel für Antipsychotika und moduliert motorische Funktionen sowie Belohnungsverarbeitung.
Der AMPA-Rezeptor ist ein ionotroper Glutamatrezeptor, der die schnelle exzitatorische synaptische Übertragung im ZNS vermittelt. Er arbeitet eng mit NMDA-Rezeptoren bei der synaptischen Plastizität zusammen.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Synapedia Evidence
Frequently checked combinations
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Risks & Harm Reduction translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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