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Ketamine is a dissociative anesthetic that is frequently used in medicine. It also has psychoactive properties and is used in some cases for the treatment of depression.
Receptor Targets
Mechanism of Action
Designations
IUPAC: Ketamin
Receptor Profile
Der κ-Opioid-Rezeptor (KOR) ist ein Gi-coupled GPCR, der Dysphorie, Sedierung und dissoziative Effekte vermitteln kann. Er wird mit Stress- und Suchtmechanismen in Verbindung gebracht.
The μ-opioid receptor (MOR) is a Gi-coupled GPCR involved in analgesia, euphoria and respiratory depression. It is the primary receptor target of most clinically used opioids.
Synapedia Evidence
Frequently checked combinations
Ketamine primarily acts as an NMDA receptor antagonist, leading to dissociation and analgesic effects. Additionally, it influences serotonergic systems, which may contribute to antidepressant effects.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 1-2 hours (IV), 1-3 hours (nasal), 2-4 hours (oral)
Peak
30 minutes (IV), 1-2 hours (nasal), 1-2 hours (oral)
Onset
1-5 minutes (IV), 5-15 minutes (nasal), 20-30 minutes (oral)
Total duration
1-2 hours (IV), 1-3 hours (nasal), 2-4 hours (oral)
After effects
Up to 24 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks & Harm Reduction is partially translated. Some details are still being expanded.
Risks
Evidence
strong
Neurotoxicity
possible
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Aggregated signals from 10 experience reports on Ketamin.
From 6 of 10 reports
Community data from 10 reports. Not a scientific assessment.
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Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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