Translated automatically – community improvements welcome.

Ketamin — Mechanism of Action

Pharmacological foundations and receptor profiles

DissoziativaNMDA (Open-Channel-Blocker)μ-Opioid (schwacher Agonist)Sigma-1 (Agonist)D2 (Partieller Agonist)HCN1 (Blocker)AMPA (indirekte Potenzierung)

Mechanisms of Action

Non-competitive antagonist at NMDA glutamate receptors (primary mechanism)

Downstream AMPA receptor potentiation — mediates rapid antidepressant effects

BDNF/TrkB signaling upregulation — synaptic plasticity and neurogenesis

Opioid receptor agonism (partial) — contributes to analgesia

Sigma-1 receptor agonist

mTOR pathway activation — rapid synaptogenesis in PFC

Laden…