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1-(2,3-dihydro-1-benzofuran-6-yl)propan-2-amine
1-(2,3-dihydro-1-benzofuran-6-yl)propan-2-amine (6-APDB) is an empathogen phenethylamine structurally related to MDMA. It primarily acts by inhibiting the reuptake of serotonin, dopamine, and norepinephrine, leading to enhanced empathogenic and stimulant effects. The substance has been mainly studied in research and recreational contexts, with limited data on long-term effects.
Translation in progress
This section is currently being translated. Content will be available soon.
View German version →Receptor Targets
Mechanism of Action
Designations
IUPAC: (2-coumaran-6-yl-1-methyl-ethyl)amine
Receptor Profile
Der 5-HT2A-Rezeptor ist ein Serotonin-Rezeptor der Klasse Gq-gekoppelter GPCRs. Er ist der primäre molekulare Angriffspunkt klassischer Psychedelika und spielt eine Rolle bei Kognition und Wahrnehmung.
Der 5-HT1A-Rezeptor ist ein Gi/Go-gekoppelter Serotoninrezeptor, der als Autorezeptor auf serotonergen Neuronen und als Heterorezeptor in verschiedenen Hirnregionen vorkommt. Er moduliert Angst, Stimmung und Kognition.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some content may appear in German.
6-APDB functions primarily as a serotonin, dopamine, and norepinephrine reuptake inhibitor.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Dosage & Duration — Translation in progress
This section is being translated. Content is available in German.
View in German →Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks & Harm Reduction is partially translated. Some content may appear in German.
Risks
Summary
Hyperthermie, Hyponatriämie und kardiovaskuläre Belastung. Comedown kann depressive Episoden auslösen. Moderates Abhängigkeitspotenzial. Neurotoxizität bei häufigem Konsum.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interactions — Translation in progress
This section is being translated. Content is available in German.
View in German →Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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