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2-[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,54S,60S,63R,68R,71S,77S)-63-amino-13,45,54,60-tetrakis(4-aminobutyl)-4,36-bis(3-carbamimidamidopropyl)-16-carbamoyl-71-[(1R)-1-hydroxyethyl]-7,39,77-tris(hydroxymethyl)-27-[(4-hydroxyphenyl)methyl]-48-methyl-33-(2-methylpropyl)-30-(2-methylsulfanylethyl)-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,62,69,72,75,78,85-tetracosaoxo-18,19,65,66,81,82-hexathia-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,61,70,73,76,79,84-tetracosazatricyclo[40.37.4.221,68]pentaoctacontan-24-yl]acetic acid
Ziconotide is a synthetic peptide used as an analgesic for severe chronic pain. It works by blocking N-type voltage-gated calcium channels, thereby inhibiting pain signal transmission in the spinal cord. Due to its potent effects and potential side effects, it is usually administered intrathecally under medical supervision.
Translation in progress
The German version has more complete content. This English page is being expanded; safety-critical risk and interaction sections may still appear while translation continues.
Receptor Targets
Mechanism of Action
Ziconotide acts through the following pharmacological mechanisms:
Designations
IUPAC: 2-[(1R,4S,7S,13S,16R,21R,24S,27S,30S,33S,36S,39S,42R,45S,48S,54S,60S,63R,68R,71S,77S)-63-amino-13,45,54,60-tetrakis(4-aminobutyl)-16-carbamoyl-4,36-bis(3-guanidinopropyl)-27-(4-hydroxybenzyl)-71-[(1R)-1-hydroxyethyl]-33-isobutyl-2,5,8,11,14,23,26,29,32,35,38,41,44,47,50,53,56,59,62,69,72,75,78,85-tetracosaketo-48-methyl-7,39,77-trimethylol-30-[2-(methylthio)ethyl]-18,19,65,66,81,82-hexathia-3,6,9,12,15,22,25,28,31,34,37,40,43,46,49,52,55,58,61,70,73,76,79,84-tetracosazatricyclo[40.37.4.221,68]pentaoctacontan-24-yl]acetic acid
Legal Status
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Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology translation in progress
English prose is being expanded. The German version currently has more detail.
Dosage & Duration translation in progress
English prose is being expanded. The German version currently has more detail.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks & Harm Reduction is partially translated. Some details are still being expanded.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interactions translation in progress
English prose is being expanded. Safety-critical structured data may still be shown when available.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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