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2-methyl-1-phenylpropan-2-amine
Phentermine is a central nervous system stimulant from the class of phenethylamines, primarily used for short-term support in weight reduction. It acts mainly by releasing norepinephrine and dopamine in the brain, leading to a reduced perception of appetite. The substance has a moderate risk profile, particularly regarding cardiovascular side effects and potential dependence. Due to its mechanism of action, phentermine should only be used under medical supervision.
Receptor Targets
Mechanism of Action
Designations
IUPAC: (1,1-dimethyl-2-phenyl-ethyl)amine
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Receptor Profile
Der Dopamintransporter (DAT) ist ein Natrium-abhängiger Monoamintransporter, der Dopamin aus dem synaptischen Spalt entfernt. Er ist ein zentrales Ziel von Stimulants und spielt eine Schlüsselrolle im Belohnungssystem.
Der 5-HT2C-Rezeptor ist ein Gq/11-gekoppelter Serotoninrezeptor, der an der Regulation von Appetit, Stimmung und Angst beteiligt ist. Er wird von verschiedenen Psychedelika als sekundäres Ziel aktiviert und moduliert dopaminerge Signalwege.
Substance Fingerprint
Pharmacological profile based on receptor binding, mechanism of action, and substance class. Limited data — interpret profile with caution.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Phentermine wirkt als Sympathomimetikum, das die Freisetzung von Neurotransmittern wie Noradrenalin und Dopamin fördert, was zu einer erhöhten Wachsamkeit und Appetitkontrolle führt.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Total duration 8-12 hours
Peak
3-4 hours
Onset
1-2 hours
Total duration
8-12 hours
After effects
2-4 hours
Start low. Individual sensitivity varies.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Summary
Mögliche Nebenwirkungen umfassen Schlaflosigkeit, erhöhter Blutdruck und Nervosität.
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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