Synapedia

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Nomifensine

Nomifensine is an atypical antidepressant that primarily acts by inhibiting the reuptake of norepinephrine and dopamine. It has been used for the treatment of depression but was withdrawn from the market due to rare but severe side effects such as hemolytic anemia. The substance does not significantly affect serotonergic systems and shows a lower risk for sedative effects. Due to its mechanism of action, Nomifensine may have mood-enhancing and drive-increasing effects.

Antidepressiva
Antidepressiva
Noradrenalintransporter
Dopamintransporter

Mechanism of Action

  • Dopamine reuptake inhibitor
  • Norepinephrine reuptake inhibitor

Names / Identifiers

IUPAC: Nomifensine

Nomifensine
24526-64-5
nomifensin
Linamiphen
(+-)-Nomifensin
(+-)-Nomifensine
Nomifensina
Nomifensinum
8-Isoquinolinamine, 1,2,3,4-tetrahydro-2-methyl-4-phenyl-
D,L-nomifensine

Mechanism of Action

Nomifensine wirkt hauptsächlich durch die Hemmung der Wiederaufnahme von Noradrenalin und Dopamin, was zu einer Erhöhung der Verfügbarkeit dieser Neurotransmitter im synaptischen Spalt führt.

Effects

stimmungsaufhellend
antriebssteigernd
euphorisierend
appetitanregend
anxiolytisch

Effects described from scientific sources. Individual experiences vary.

Dosage

Safety NoteIndividual variation, start at a low dose, no medical advice.

Individual sensitivity varies. Not a dosage recommendation.

Duration

Peak4-6 hours
NotesEffect may vary depending on individual metabolism.
Onset1-2 hours
Total12-24 hours
After EffectsVariable

Risks & Warnings

Warnings

  • Pregnancy
  • Breastfeeding
  • History of hemolytic anemia

Known Risks

  • high
  • Seltene, aber schwere Nebenwirkungen wie hämolytische Anämie.

Safer Use

  • Start at a low dose
  • Regular medical check-ups

Harm reduction tips do not replace medical advice.

Known Interactions

  • MAO inhibitors
  • Serotonin reuptake inhibitors

This list is not exhaustive. Interactions can have unpredictable effects.

Legal Status

ATNicht mehr zugelassen
CHNicht mehr zugelassen
DENicht mehr zugelassen
USNicht mehr zugelassen
NotesNomifensine wurde aufgrund schwerwiegender Nebenwirkungen vom Markt genommen.

Not legal advice. Status may change.