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Modafinil is a wakefulness-promoting stimulant primarily used for the treatment of narcolepsy and other sleep disorders. It primarily acts by inhibiting the reuptake of dopamine and norepinephrine as well as by modulating the orexin system. The substance has a lower potential for abuse than classic stimulants but can cause side effects with improper use. Modafinil is also used off-label to enhance cognitive performance.
Class
Nootropika
Pharmacological context
Mechanism
Modafinil ist ein Wachmacher mit komplexem mechanism of action. Primär:...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: 2-benzhydrylsulfinylacetamide
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
Modafinil ist ein Wachmacher mit komplexem mechanism of action. Primär: schwacher DAT-Reuptake-Inhibitor (erhöht synaptisches Dopamin moderat, deutlich schwächer als Methylphenidat oder Amphetamine). Auch schwacher NET-Reuptake-Inhibitor. KRITISCH: Die wachheitsfördernde Wirkung entsteht hauptsächlich durch indirekte Aktivierung des Orexin/Hypocretin-Neuron-Systems im Hypothalamus mit nachgelagerter Aktivierung des histaminergen (Tuberomammillary Nucleus, H1), adrenergen und dopaminergen Wachheitssystems. Das spezifische Wirkmuster (subtil auf DAT/NET, aber Orexin-Aktivierung) erklärt das niedrigere Missbrauchspotential trotz DAT-Bindung im Vergleich zu klassischen Stimulants.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 200 mg
Total duration 10–12 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 100 mg |
| Reported | 200 mg |
| Strong | 400 mg |
Oral
Onset
30–60 minutes
Peak
2–4 hours
Total duration
10–12 hours
After effects
2–4 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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