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LSD — Mechanism of Action

Pharmacological foundations and receptor profiles

Psychedelika5-HT2A (Partialagonist)5-HT2C (Agonist)5-HT1A (Agonist)D2 (Agonist)D1 (Agonist)TAAR1 (Agonist)5-HT6 (Agonist)

Overview Effects Dosage Duration Timeline Mechanism Interactions Risks Safer Use Experiences

Mechanisms of Action

Partial agonist at 5-HT2A serotonin receptors (primary psychedelic mechanism)

Partial agonist at 5-HT2C and 5-HT1A receptors

Partial agonist at dopamine D2 receptors

Agonist at TAAR1 (trace amine-associated receptor 1)

Disrupts thalamocortical sensory gating

More Information

Effects & Pharmacology
Interactions