Laden…
(6aR,9R)-N,N-diethyl-7-methyl-4-propanoyl-6,6a,8,9-tetrahydroindolo[4,3-fg]quinoline-9-carboxamide
1-Propionyl-LSD (1P-LSD) is a semi-synthetic lysergamide and structural analogue of LSD. The substance is enzymatically hydrolysed to LSD in the body and is therefore classified as a prodrug. Effects, dosage, and risk profile are largely identical to LSD. 1P-LSD has a half-life of approximately 10–12 hours and acts primarily as a partial agonist at the 5-HT2A receptor. Psychedelic effects include altered perception, visual hallucinations, and changes in cognition.
Class
Psychedelika
Pharmacological context
Mechanism
1P-LSD (1-Propionyl-LSD) ist eine Prodrug für LSD. In vitro...
Short read on known pharmacology
Interactions
No curated pairs visible
Curated visible combinations
Risk theme
Interpret risks carefully
Condensed from structured notes
Receptor Targets
Mechanism of Action
Designations
IUPAC: 1P-LSD
Legal Status
Legal status not verified by official sources. Please check current legislation independently.
Information without guarantee. Not legal advice.
Synapedia Evidence
Effects & Pharmacology is partially translated. Some details are still being expanded.
1P-LSD (1-Propionyl-LSD) ist eine Prodrug für LSD. In vitro pharmakologisch nahezu inaktiv an 5-HT2A (Ki >1000 nM). In vivo spalten hepatische und intestinale Amidasen/Esterasen die 1-Propionyl-Gruppe, um LSD freizusetzen (Konversionshalbwertszeit ~1h). Die gesamte pharmakologische Aktivität stammt ausschließlich vom LSD-Metaboliten: 5-HT2A-Partialagonismus, 5-HT1A, 5-HT2C, D1/D2-Agonismus. Das Wirkprofil ist pharmakologisch identisch zu LSD, der Wirkungseintritt ist leicht verzögert durch die Prodrug-Konversion.
Known Effects
Individual effects may vary significantly. These are pharmacologically documented effects.
Reported range 100–200 µg
Total duration 8–12 hours
Oral
| Tier | Dosage |
|---|---|
| Light | 50–100 µg |
| Reported | 100–200 µg |
| Strong | 200–300 µg |
Oral
Onset
30–60 minutes
Peak
2–4 hours
Total duration
8–12 hours
After effects
2–6 hours
Avoid uncertain dosage claims and do not infer numbers when data is unclear.
Dose sensitivity varies greatly between individuals. Body weight, tolerance, route of administration, combinations, and pre-existing conditions significantly affect outcomes. These figures are not dosing recommendations — they describe reported ranges, not safe amounts.
Risks
Safer Use
The risks listed may be incomplete. Especially for research chemicals and rare substances, available data is limited.
Interaction details from the knowledge layer are still being translated.
Interaction data is based on known mechanisms. Unknown or rare interactions are possible and may be life-threatening.
Based on substance class, receptors, mechanisms, and effect profile.
This information is for scientific and harm-reduction purposes only. It does not constitute medical advice.
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