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maoi and snri — Interaction & Risk | Synapedia

Interaction Checker

maoi & snri

Absolut kontraindiziert: Serotonerge und noradrenerge Krise

Critical Risk

Curated Data

Risk Assessment

Critical Risk

MAOI hemmen den Abbau von Serotonin und Noradrenalin, während SNRI deren Wiederaufnahme blockieren. Diese doppelte Blockade führt zu massiv erhöhten Spiegeln beider Neurotransmitter. Neben dem Serotoninsyndrom besteht auch das Risiko einer hypertensiven Krise durch exzessive Noradrenalin-Akkumulation.