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DXM and tca — Interaction & Risk | Synapedia

Interaction Checker

DXM & tca

Serotoninsyndrom und kardiotoxische Wechselwirkungen

High Risk

Curated Data

Risk Assessment

High Risk

DXM und TCA hemmen beide die Serotonin-Wiederaufnahme. TCA blockieren zusätzlich Natriumkanäle am Herzen. Die Kombination erhöht das Risiko sowohl für ein Serotoninsyndrom als auch für kardiale Arrhythmien. DXM wird zudem über CYP2D6 metabolisiert, das von TCA kompetitiv gehemmt wird.