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Substance Comparison
Methamphetamin stands out with markedly stronger addiction risk. Methamphetamin stands out with markedly stronger stimulation. Methamphetamin stands out with markedly stronger body load. SSRI leans slightly higher in sedation.
Despite belonging to different classes, these substances share receptor activity at SERT, which may produce overlapping effects.
Methamphetamin has significantly higher addiction risk
Methamphetamin has significantly higher stimulation
Methamphetamin has significantly higher body load
SSRI has somewhat higher sedation
| Methamphetamin | SSRI | |
|---|---|---|
| Class | Stimulanzien | Antidepressiva |
| Risk Level | high | low |
| Mechanisms | DAT-Umkehrtransport, NET-Umkehrtransport, SERT-Umkehrtransport, TAAR1-Agonist | Selektive Serotonin-Wiederaufnahmehemmung |
| Receptors | DAT, NET, SERT, TAAR1 | SERT |
| Effects | Euphorie, Erhöhte Wachsamkeit, Appetitlosigkeit, Schlaflosigkeit, Angst | — |
| Evidence | strong | — |
Methamphetamin ist ein potenteres Analogon von Amphetamin mit höherer Lipophilie und schnellerer ZNS-Penetration. Der Wirkmechanismus ist analog zu Amphetamin: TAAR1-Agonismus → PKA/PKC-Aktivierung → Phosphorylierung von DAT und NET → massiver Dopamin- und Noradrenalin-Reverse-Transport. Zusätzlich VMAT2-Inhibition setzt vesikuläre Monoamine frei. Im Vergleich zu Amphetamin: stärkere Dopaminfreisetzung, längere Halbwertszeit (~10-12h vs. 8-12h), höheres Abhängigkeitspotential und stärkere neurotoxische Effekte. Die Methyl-Gruppe erhöht die Lipophilie und führt zu schnellerem Wirkungseintritt und intensiveren Effekten.
Safer-use data available on substance page
Evidence: strong · Sources: 4
Evidence: not assessed · Sources: 2