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Substance Comparison
In terms of stimulation, Koffein scores notably higher. In terms of addiction risk, Koffein scores notably higher.
Despite belonging to different classes, these substances share receptor activity at A1 and A2A, which may produce overlapping effects.
Koffein has notably higher stimulation
Koffein has notably higher addiction risk
| Koffein | Theobromine | |
|---|---|---|
| Class | Stimulanzien | Methylxanthine |
| Risk Level | low | — |
| Mechanisms | Adenosinrezeptor-Antagonist | adenosine receptor antagonist, PDE inhibitor |
| Receptors | A1, A2A | A1, A2A, D1, D2, 5-HT1, 5-HT2, CB1, DAT, SERT |
| Effects | — | Gesteigerte Wachheit und Konzentration, Erhöhter Antrieb und Motivation, Euphorie und gesteigertes Selbstvertrauen, Verminderte Müdigkeit, Gesteigerte körperliche Leistungsfähigkeit |
| Evidence | — | unknown |
Theobromin wirkt hauptsächlich als Adenosinrezeptor-Antagonist und hemmt die Phosphodiesterase, was zu einer Erhöhung der intrazellulären cAMP-Spiegel führt.
No harm reduction data available
Safer-use data available on substance page
Evidence: not assessed · Sources: 2
Evidence: unknown · Sources: 2